Novel mathematical model based on cellular automata for study of Alzheimer’s disease progress

چکیده مقاله

In recent years, extensive research has been done on the prediction, treatment, and recognition of Alzheimer’s disease (AD). The study of AD emerging and progression in the first years is valuable due to the nature of AD. Among scientific works, mathematical modeling of AD is an efficient way of studying the influence of various parameters on AD emerging. This paper proposes a novel model based on Cellular Automata (CA) for the study of AD's progress. In our model, the synapses of each neuron have been considered as square cells located around the central cell. The key parameter for AD progression in our model is amyloid-β (Aβ), which is calculated by differential rate equations of the Puri-Li model. Based on the proposed model in this article, we introduce a new definition of AD Rate for an M × L-neuron network, which can expand to the whole hippocampus space. To better illustrate the mechanism of …