Alterations in miR-۱۲۸-۱ and some blood lipoproteins following ۱۲ weeks of concurrent aerobic and strength training in obese middle-aged men [In Persian]

Background and Objective: Obesity can disrupt health by causing various diseases and especially by causing disturbances in blood lipid profiles. Since very few studies have been done in relation to miRNAs related to obesity and their role in causing disturbances in blood lipoproteins, therefore the aim of this research was the alterations in miR-128-1 and blood lipoproteins following 12 weeks of concurrent aerobic and strength training (CAST) in obese middle-aged men.
Materials and Methods: 30 middle-aged men (40-50 years old) and obese (BMI≥30) randomly and based on fat percentage, aerobic capacity (VO_2max) and one repetition maximum (1-RM) were assigned to three groups 1-CAST in one day 2-CAST on different days and       3-control group. Blood samples were collected from the subjects 48 hours before and after 12 weeks of concurrent training, in order to analyze miR-128-1 indices and blood lipid profiles. One-way repeated measures ANOVA and paired sample t-test were used to analyze the data.
Results: The results showed that after 12 weeks of CAST training, both training groups experienced a significant decrease in miR-128-1, HDL-C, LDL-C, triglyceride and cholesterol indices compared to the control group (P<0/05).
Conclusion: It seems that CAST training can improve lipid profiles by affecting obesity-related miRNAs, especially miR-128-1, and thereby help improve health.