| نویسندگان | Sara Abdolrahmani, Sabra Fouladi, Seyedeh Zahra Bakhti |
|---|---|
| همایش | Seventh International Conference on Biology and Earth Sciences |
| تاریخ برگزاری همایش | 2025-3-13 |
| محل برگزاری همایش | همدان |
| نوع ارائه | سخنرانی |
| سطح همایش | بین المللی |
چکیده مقاله
Abstract
Since most therapeutic agents cannot penetrate the blood-brain barrier (BBB), this poses a
considerable challenge to effectively treating central nervous system (CNS) disorders. Consequently,
numerous drugs demonstrate poor targeting of the brain, resulting in diminished therapeutic efficacy
and heightened side effects from off-target buildup. Recent progress in materials science, nanotech,
and biomaterials presents innovative methods for addressing this challenge and improving CNS drug
delivery effectiveness. This review investigates the physiological composition and functions of the
different cells within the BBB, along with novel approaches to improve drug permeability, including
ligand conjugation, intranasal delivery, passive transcytosis, and stimulus-induced disruption. By
analyzing recent studies, we highlight the main challenges and opportunities in the future development
of brain-targeted drug delivery systems. Our primary goal is to improve knowledge about methods to
optimize drug delivery across the blood-brain barrier, facilitating the creation of more effective
therapies for central nervous system conditions
کلیدواژهها: BBB, CNS, Nanoparticles, Targeted Therapy, Nanomedicine