Emerging Functional Roles of Long Noncoding RNA and LncRNAEncoded Peptides in Glioma

چکیده مقاله

The role of long non-coding RNAs (lncRNAs) and peptides encoded by lncRNAs
in glioma is an emerging area of research that highlights the complexity of gene regulation and
the potential for novel therapeutic targets. Traditionally, lncRNAs were thought to function
solely as regulatory molecules without coding potential. However, recent studies have revealed
that some lncRNAs contain open reading frames (ORFs), which can indeed encode small
peptides that play significant roles in tumor biology, including glioma. LncRNAs and peptides
derived from them play multifaceted roles in glioma biology, influencing tumor progression
and therapeutic response. Some of them play the role of oncogenic and some tumor suppressor.
Their ability to regulate key cellular processes and interact with various signaling pathways
positions them as promising candidates for further investigation in glioma research. As our
understanding of lncRNA and lncRNA-derived peptide functions deepens, it is likely that they
will become integral components of diagnostic and therapeutic strategies in the management
of gliomas. This study will explore the mechanisms through which these lncRNAs and
lncRNA-derived peptides contribute to glioma pathogenesis, their functional implications, and
potential therapeutic applications.