بررسی آسیب اکسایشی در نمونه های سرطان پروستات و رابطه آن با بیان ماتریکس متالوتروتئیناز۹ و ژنهای دخیل در تنظیم پیام رسانی یون کلسیم

چکیده:

Oxidative stress is defined as excess production of reactive oxygen species (ROS) relative to antioxidant defense. Oxidative stress plays a crucial role in the development of age-related diseases including arthritis, diabetes, dementia, cancer, atherosclerosis, vascular diseases, obesity, osteoporosis, and metabolic syndromes. Antioxidants control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals via different mechanisms. Prostate cancer is one of the most common health threats for men in the developed world. Prostate cancer risk increases strongly with age and >85% of newly diagnosed individuals are >60 years of age. The aim of this research is to determination of antioxidant balance (Catalase, SOD, GSH/GSSG, and Reactive Oxygen Species (ROS)) in patients with prostate cancer and identification of genes (MMP9, ADP ribosyl cyclase, CD38, CD82) related to oxidative stress and calcium signaling by western blotting method.